Oleg Alexeyev

Contact Information

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Position:

Physician

personbild

Works at:

Medical Biosciences

Department:

Patologi

Address:

Umeå universitet
SE-901 85 Umeå
Sverige

Visiting Address:

By 6M, vån 2, Sjukhusområdet

Email:

oleg.alexeyev@umu.seEmail 2

oleg.alexeyev@medbio.umu.seEmail 1

Lync:

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Web Page:

http://www.medbio.umu.se/om-institutionen/personal/alexeyev-oleg/ Web Page

Research project

Our research is aiming at investigating the connection between Propionibacterium acnes biofilms and various skin diseases affecting hair follicles. Furthermore, new insights into the complex network of bacterial infection and inflammatory reactions are explored. Research is also focussing on the composition of the skin microbiome and interactions of members thereof.
More than 80% of young adolescents are affected by acne vulgaris worldwide. The human skin commensal bacterium P. acnes has long been associated with inflammatory acne. However, its precise role in the disease and its interaction with the human immune system remains to be elucidated. So far, studies addressing the localization of P. acnes are mainly based on culture techniques. To provide a real insight into the pathogenic role of P. acnes in acne vulgaris, the bacterium should be visualized within its natural habitat. Methodologies enabling direct visualization of bacteria, such as fluorescence in situ hybridization (FISH) and immunofluorescence microscopy (IFM), either individually or combined are accurate at establishing micro-environment colonization. Results so far have shown the presence of two anatomically distinct populations of P. acnes – epidermal and follicular.

P. acnes biofilm in a hair follicle labelled       Hair follicle showing a mixed
with P. acnes specific monoclonal                 population of P. acnes phylotypes
antibody (green). Brit J Dermatol,                (yellow and red). Brit J
2012, 167:50-58.                                      Dermatol,  2012, 167:50-58.

Publications

Author

Title

Year sorteringsordning

Fulltext

Alexeyev, Oleg A.

Is it time to switch on or off the green light for ultraviolet-induced red fluorescence as a surrogate marker for Propionibacterium acnes in vivo?
Experimental dermatology, 26(1): 26-27

2017

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Omer, Hélène
McDowell, Andrew
Alexeyev, Oleg A.

Understanding the role of Propionibacterium acnes in acne vulgaris: The critical importance of skin sampling methodologies
Clinics in Dermatology, 35(2): 118-129

2017

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Jahns, Anika C.
Eilers, Hinnerk
Alexeyev, Oleg A.

Transcriptomic analysis of Propionibacterium acnes biofilms in vitro
Anaerobe, 42: 111-118

2016

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Jahns, Anika C.
Alexeyev, Oleg A.

Microbial colonization of normal skin: Direct visualization of 194 skin biopsies
Anaerobe, 38: 47-49

2016

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Eilers, Hinnerk
Alexeyev, Oleg A.

Effect of GT-Peptide 10 and Triethyl Citrate on P. acnes Biofilm Formation, Viability, and Dispersion
Journal of drugs in dermatology, 15(6): 778-781

2016

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Witek, Barbara
El Wakil, Abeer
Nord, Christoffer; et al.

Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism
PLoS ONE, 10(5)

2015

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Jahns, Anika C
Eilers, Hinnerk
Ganceviciene, R.; et al.

Propionibacterium species and follicular keratinocyte activation in acneic and normal skin
British Journal of Dermatology, 172(4): 981-987

2015

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Jahns, Anika C.
Lundskog, Bertil
Nosek, Daniel; et al.

Microbiology of folliculitis decalvans: a histological study of 37 patients
Journal of the European Academy of Dermatology and Venereology, 29(5): 1025-1026

2015

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Jahns, Anika
Killasli, Hassan
Nosek, Daniel; et al.

Microbiology of hidradenitis suppurativa (acne inversa): a histological study of 27 patients
Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 122(9): 804-809

2014

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Jahns, Anika C.
Alexeyev, Oleg A.

Three dimensional distribution of Propionibacterium acnes biofilms in human skin
Experimental dermatology, 23(9): 687-689

2014

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Researchers

Helene Omer