Oleg Alexeyev

Contact Information

Position:

Researcher

personbild

Works at:

Medical Biosciences

Department:

Patologi

Address:

Umeå universitet
SE-901 85 Umeå
Sverige

Visiting Address:

By 6M, vån 2, Sjukhusområdet

Tel:

+46 90 785 28 41

Facsimilie:

+46 90 785 44 84

Email:

oleg.alexeyev@medbio.umu.seEmail 1

oleg.alexeyev@umu.seEmail 2

Lync:

Get in touch via Lync

Web Page:

http://www.medbio.umu.se/om-institutionen/personal/alexeyev-oleg/ Web Page

Research project

Our research is aiming at investigating the connection between Propionibacterium acnes biofilms and various skin diseases affecting hair follicles. Furthermore, new insights into the complex network of bacterial infection and inflammatory reactions are explored. Research is also focussing on the composition of the skin microbiome and interactions of members thereof.
More than 80% of young adolescents are affected by acne vulgaris worldwide. The human skin commensal bacterium P. acnes has long been associated with inflammatory acne. However, its precise role in the disease and its interaction with the human immune system remains to be elucidated. So far, studies addressing the localization of P. acnes are mainly based on culture techniques. To provide a real insight into the pathogenic role of P. acnes in acne vulgaris, the bacterium should be visualized within its natural habitat. Methodologies enabling direct visualization of bacteria, such as fluorescence in situ hybridization (FISH) and immunofluorescence microscopy (IFM), either individually or combined are accurate at establishing micro-environment colonization. Results so far have shown the presence of two anatomically distinct populations of P. acnes – epidermal and follicular.

P. acnes biofilm in a hair follicle labelled       Hair follicle showing a mixed
with P. acnes specific monoclonal                 population of P. acnes phylotypes
antibody (green). Brit J Dermatol,                (yellow and red). Brit J
2012, 167:50-58.                                      Dermatol,  2012, 167:50-58.

Publications

Author

Title

Year sorteringsordning

Fulltext

Jahns, Anika C.
Lundskog, Bertil
Berg, Johanna; et al.

Microbiology of folliculitis: a histological study of 39 cases
Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 122(1): 25-32

2014

-

Jahns, Anika C
Oprica, Cristina
Vassilaki, Ismini; et al.

Simultaneous visualization of Propionibacterium acnes and Propionibacterium granulosum with immunofluorescence and fluorescence in situ hybridization
Anaerobe, 23: 48-54

2013

-

Alexeyev, Oleg A
Zouboulis, Christos C

Shooting at skin propionibacterium acnes: to be or not to be on target
Journal of Investigative Dermatology, 133(9): 2292-2294

2013

-

Alexeyev, Oleg A.

Bacterial landscape of human skin: seeing the forest for the trees
Experimental dermatology, 22(7): 443-446

2013

-

Jahns, Anika C
Golovleva, Irina
Palmer, Ruth H; et al.

Spatial distribution of bacterial-fungal communities in facial skin
Journal of dermatological science (Amsterdam), 70(1): 71-73

2013

-

Jahns, Anika C.
Lundskog, Bertil
Dahlberg, Ida; et al.

No link between rosacea and Propionibacterium acnes
Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 120(11): 922-925

2012

-

Jahns, Anika C
Lundskog, Bertil
Ganceviciene, R; et al.

An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case-control study
British Journal of Dermatology, 167(1): 50-58

2012

-

Alexeyev, Oleg A
Lundskog, Bertil
Ganceviciene, Ruta; et al.

Pattern of tissue invasion by Propionibacterium acnes in acne vulgaris
Journal of dermatological science (Amsterdam), 67(1): 63-66

2012

-

Jahns, Anika C.
Alexeyev, Oleg A.

Direct visualization of a gravid Demodex mite in human skin biopsy
Journal der Deutschen Dermatologischen Gesellschaft, 10(5): 358-359

2012

-

Alexeyev, O. A.
Jahns, A. C.

Sampling and detection of skin Propionibacterium acnes: Current status
Anaerobe, 18(5): 479-483

2012

-


Page Editor: Åsa Lundsten
2012-11-06

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Group members

Researchers

Hinnerk Eilers
Anika Jahns