Till umu.se

Maréne Landström


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Verksam vid:

Medicinsk biovetenskap




Ställföreträdande prefekt


Umeå universitet
SE-901 85 Umeå


By 6M, Sjukhusområdet


+46 90 785 44 84


marene.landstrom@umu.seE-post 1

marene.landstrom@medbio.umu.seE-post 2


Ta kontakt via Lync


http://www.medbio.umu.se/om-institutionen/personal/landstrom-marene/ Webbsida

Research Project

TGF-β signaling - Tumor biology in prostate cancer

Prostate cancer is the most common tumor in men in the Western society and the incidence is expected to increase. However, we still lack good molecular tools to identify aggressive prostate cancer. This is a reason why many men with prostate cancer need to undergo radical prostatectomy with the risk of severe complications.

Our aim is to identify the molecular signaling pathways leading to advanced prostate cancer. This knowledge will be used to design novel therapeutic strategies and improved molecular diagnostic tools.

Our research is focused on TGFβ signal transduction, tumor biology and molecular pathology, particularly in prostate cancer. TGFβ plays an important role for regulation of migration and invasion in several kinds of cancer cells, including prostate cancer cells.

In aggressive prostate cancer there is a correlation between the amount of secreted TGFβ and poor prognosis with development of metastases. We have found that the ubiquitin-ligase TRAF6 is a crucial co-regulator of TGFβ-induced non-canonical and oncogenic responses, as it associates with the TGFβ type I receptor. TRAF6 promotes also expression and activation of proteolytic enzymes, such as TACE and presenilin1, which cleaves the TGFβ type I receptor to liberate its intracellular domain (ICD). The generated ICD translocate to the nucleus in an unknown manner, where it contributes to gene transcription of pro-invasive and metastatic genes. We focus our research on exploring how TGFβ regulates invasive and metastatic behavior of prostate cancer cells. We have access to unique collections of biobanked material at Biobanken Norr in collaboration with reseachers here in Umeå.

We collaborate with the Ludwig Institute for Cancer Research, Uppsala Branch www.licr.uu.se, where we in detail, study molecular mechanisms whereby TGFβ regulates specific oncogenic cellular responses. See our annual report for the Apoptotic Signaling Group on www.licr.uu.se.

We collaborate with SciLifeLab Drug Discovery Platform in order to design novel and more specific cancer drugs.




År sorteringsordning


Hamidi, Anahita
Song, Jie
Thakur, Noopur; et al.

TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α
Science Signaling, 10(486)



Holst, Mikkel Roland
Vidal-Quadras, Maite
Larsson, Elin; et al.

Clathrin-Independent Endocytosis Suppresses Cancer Cell Blebbing and Invasion
Cell reports, 20(8): 1893-1905



Bugaytsova, Jeanna A.
Björnham, Oscar
Chernov, Yevgen A.; et al.

Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence
Cell Host and Microbe, 21(3): 376-389



Song, Jie
Mu, Yabing
Li, Chunyan; et al.

APPL proteins promote TGF beta-induced nuclear transport of the TGF beta type I receptor intracellular domain
OncoTarget, 7(1): 279-292



Tumkur Sitaram, Raviprakash
Mallikarjuna, Pramod
Landström, Maréne; et al.

Transforming growth factor-β promotes aggressiveness and invasion of clear cell renal cell carcinoma
OncoTarget, 7(24): 35917-35931



Mu, Yabing
Zang, Guangxiang
Engstrom, U.; et al.

TGF beta-induced phosphorylation of Par6 promotes migration and invasion in prostate cancer cells
British Journal of Cancer, 112(7): 1223-1231



Yakymovych, Ihor
Yakymovych, Mariya
Zang, Guangxiang; et al.

CIN85 modulates TGF beta signaling by promoting the presentation of TGF beta receptors on the cell surface
Journal of Cell Biology, 210(2): 319-332



Sundar, Reshma
Gudey, Shyam Kumar
Heldin, Carl-Henrik; et al.

TRAF6 promotes TGF beta-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGF beta type I receptor
Cell Cycle, 14(4): 554-565



Thakur, Noopur
Gudey, Shyam Kumar
Marcusson, Anders; et al.

TGF beta-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1
Cell Cycle, 13(15): 2400-2414



Gudey, Shyam Kumar
Sundar, Reshma
Mu, Yabing; et al.

TRAF6 stimulates the tumor-promoting effects of TGF beta type I receptor through polyubiquitination and activation of Presenilin 1
Science Signaling, 7(307)



Sidansvarig: Clas Wikström